Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets.
| PAG Title | Mitochondrial genes; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. |
| PAG ID | MAX001957 |
| Type | A |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,374 |
| Information Content | Rich |
| Other IDs | M9433 |
| Base PAG ID | MAX001957 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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